GPCR (G protein-conjugated receptor) is a seven-time transmembrane protein expressed on the cell surface, and it is closely related to many human diseases, for example, cardiovascular diseases, cancer, mental disorders, diabetes and obesity, various inflammatory diseases and so on. It can regulate a variety of physiological processes, and it is currently a large family of drug target proteins. Therefore, it is the drug target of most interest to researchers and a key research object of the pharmaceutical industry.